Researchers from UCLA's Jonsson Comprehensive Cancer Center have discovered that specific types of bacteria that live in the gut are major contributors to lymphoma.
Published in the journal Cancer Research, the study was led by Robert Schiestl.
In rodents, intestinal bacteria influence obesity, intestinal inflammation and certain types of epithelial cancers. However, little is known about the identity of the bacterial species that promote the growth of, or protect the body from, cancer, or about their effect on lymphoma.
Up to 1,000 different species of bacteria ( intestinal microbiota ) live in the human gut. Intestinal microbiota number 100 trillion cells; over 90% of the cells in the body are bacteria. The composition of each person's microbiome is very different, due to the types of bacteria people ingest early in their lives, as well as the effects of diet and lifestyle.
Schiestl's group wanted to determine whether differences in peoples' microbiomes affect their risk for lymphoma, and whether changing the bacteria can reduce this risk. They studied mice with ataxia-telangiectasia ( A-T ), a genetic disease that in humans and mice is associated with a high rate of B-cell lymphoma. They discovered that, of mice with A-T, those with certain microbial species lived much longer than those with other bacteria before developing lymphoma, and had less of the gene damage ( genotoxicity ) that causes lymphoma.
This study is the first to show a relationship between intestinal microbiota and the onset of lymphoma. Given that intestinal microbiota is a potentially modifiable trait, these results hold considerable promise for intervention of B-cell lymphoma and other diseases.
The researchers also were able to create a detailed catalog of bacteria types with promoting or protective effects on genotoxicity and lymphoma, which could be used in the future to create combined therapies that kill the bacteria that promote cancer and increase the presence of the bacteria that protect from cancer. ( Xagena )
Source: University of California - Los Angeles ( UCLA ), 2013